96-53-7 (2-巯基噻唑啉,2-Mercaptothiazoline)

_98%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Amino alkanethiols from amino alcohols via aminoalkyl sulfates and thiazolidinethiones

Owen, Terence C., Journal of the Chemical Society [Section] C: Organic, 1967, (15), 1373-6

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Sulfuric acid ; 20 °C; 30 min, rt; 45 - 145 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; rt; 4 h, rt → 45 °C; 45 °C → 55 °C; 55 °C

参考文献：

A study of synthesis of 2-mercaptothiazoline

Xiao, Feng, Chongqing Shifan Daxue Xuebao, 2008, 25(4), 79-81

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; 16 h, 100 °C; 100 °C → rt

参考文献：

A Versatile Synthesis of Various Substituted Taurines from Vicinal Amino Alcohols and Aziridines

Chen, Ning; Jia, Weiyi; Xu, Jiaxi, European Journal of Organic Chemistry, 2009, (33), 5841-5846

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Sulfuric acid
1.2 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Synthesis of chrysanthemic amide containing lidinone-ring

Zhang, Yin-quan; Lu, Ze-kai; Li, Guo-liang; Guo, Shi-heng; Chen, Bing-xu, Youji Huaxue, 2001, 21(5), 380-382

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Sulfuric acid
1.2 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Two one-step methods for the synthesis of 2-thiazolidinethione

Zhang, Yinquan; Xu, Zhongyi; Liang, Wanwei; Xu, Yanhua; Chen, Jiangjun, Huaxue Shiji, 2000, 22(6),

合成路线：1 步

119216-27-2

_86%

反应条件：

1.1 Reagents: Semicarbazide Solvents: Methanol , Dichloromethane

参考文献：

A mild and efficient cleavage of symmetrical disulfides using semicarbazide and thiosemicarbazide

Maiti, Samarendra N.; Singh, Maya P.; Spevak, Paul; Micetich, Ronald G.; Reddy, Andhe V. Narender, Journal of Chemical Research, 1988, (8), 256-7

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 6 h, rt

参考文献：

Synthesis of 2-thiazolidinone

Weng, Jian-quan; Liu, Hui-jun; Tan, Cheng-xia; Shen, De-long, Zhejiang Gongye Daxue Xuebao, 2005, 33(1), 103-105

合成路线：1 步

_85%

反应条件：

1.1 Solvents: Water

参考文献：

Mercapto amines. I. 2-Mercaptoethylamine and its N-substituted derivatives

Rachinskii, F. Yu.; Slavachevskaya, N. M.; Ioffe, D. V., Zhurnal Obshchei Khimii, 1958, 28, 2998-3004

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 30 °C; 7 h, reflux; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

A Convenient Synthesis of New Annelated Pyrimidines and Their Biological Importance

Wahab Khan, M.; Uddin, Mohammed Kabir; Ali, Morshed; Rahman, Mohammad S.; Rashid, Mohammad Abdur; et al, Journal of Heterocyclic Chemistry, 2014, 51,

合成路线：1 步

_83%

反应条件：

1.1 Catalysts: 1H-Imidazolium, 3-butyl-1,2-dimethyl-, acetate (1:1) ; 6 h, 130 °C

参考文献：

BmmimOAc-catalyzed direct condensation of 2-(arylamino) alcohols to synthesize 3-arylthiazolidine-2-thiones

Chen, Bihua; Elageed, Elnazeer H. M.; Zhang, Yongya; Gao, Guohua, Wuli Huaxue Xuebao, 2018, 34(8), 952-958

合成路线：1 步

137-26-8

60-23-1

_83%

反应条件：

1.1 Solvents: Water ; 2 - 3 h, 120 °C

参考文献：

An environmentally benign and efficient synthesis of substituted benzothiazole-2-thiols, benzoxazole-2-thiols, and benzimidazoline-2-thiones in water

Liu, Xing; Liu, Min; Xu, Wan; Zeng, Meng-Tian; Zhu, Hui; et al, Green Chemistry, 2017, 19(23), 5591-5598

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol , Water ; 4 h, 40 - 50 °C

参考文献：

Design and synthesis of 3-(1-phenylethyl)thiazolidine-2-thione derivatives with potential biological activities

Li, Hong-xin; Chen, Xiao-tao; Xu, Liang-zhong, Chemical Research in Chinese Universities, 2011, 27(3), 431-434

合成路线：1 步

140-90-9

_76%

参考文献：

Studies on synthesis and antihypertensive activity of amlodipine derivatives

Xu, Yungen; Chen, Zhong; Yang, Youyao; Hua, Weiyi; Jiang, Zhenzhou, Zhongguo Yaoke Daxue Xuebao, 2001, 32(6), 412-417

合成路线：1 步

_74%

反应条件：

1.1 Reagents: Sulfuric acid ; 0 °C; 10 min, 0 °C; 0 °C → 250 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; 3.5 h, rt → 45 °C

参考文献：

Method for synthesizing Tebipenem intermediate

, China, , ,

合成路线：1 步

2002-24-6

_71%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water ; < 50 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ; < 50 °C; 3.5 h, reflux; cooled

参考文献：

Synthesis of E-β-farnesene analogues containing five-membered azaheterocycles and their biological activity

Kang, Tie-Niu; Ling, Yun; Rui, Chang-Hui; Yang, Xin-Ling; Fan, Xian-Lin; et al, Youji Huaxue, 2008, 28(4), 617-621

合成路线：1 步

_68%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; rt → 40 °C; 1 h, 40 °C; 3 h, 40 °C

参考文献：

Synthesis and biological evaluation of thiazolidine-2-thione derivatives as novel xanthine oxidase inhibitors

Wang, Mu-Xuan; Qin, Hong-Wei; Liu, Chao ; Lv, Shen-Ming; Chen, Jia-Shu; et al, PLoS One, 2022, 17(5),

合成路线：1 步

_68%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ; rt; 3 h, 40 °C

参考文献：

Synthetic method and application of 3-benzyl-1,3-thiazole-2-thioketone

, China, , ,

合成路线：1 步

_68%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; 16 h, 100 °C

参考文献：

Process for synthesis of Tebipenem Pivoxil side chain

, China, , ,

合成路线：1 步

107-35-7

_68%

反应条件：

1.1 Reagents: Potassium hydroxide

参考文献：

Reaction of 2-thiazolidinethione with halohydrocarbon: synthesis of novel N-alkylated 2-thiazolidinethione and S-alkylated thiazoline derivatives

Liu, Yufa; Liu, Junwei; Liu, Xiuming, Heterocyclic Communications, 2010, 16(4-6), 275-278

合成路线：1 步

51983-26-7

_65%