96605-66-2 (N-乙基-N-3-[(3-二甲胺基-1-氧代-2-丙稀基-)苯基-]乙酰胺,N-3-(3-Dimethylaminoacryloyl)phenyl-N-ethylacetamide)

_100%

反应条件：

1.1 Solvents: Acetonitrile ; 10 min, 180 °C

参考文献：

Preparation of 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_95%

反应条件：

1.1 rt → reflux; 5.5 h, reflux
1.2 Solvents: Dichloromethane ; 2 min, reflux

参考文献：

Zaleplon and its preparation method thereof

, China, , ,

合成路线：1 步

_92%

反应条件：

1.1 rt → 120 °C; 5 h, 120 °C

参考文献：

Synthesis of N-[3-((3-dimethylamino)-1-oxo-2-propenyl)phenyl]-N-ethylacetamide

Cheng, Qing-fang; Wang, Qi-fa; Bao, Jing-yan; Ye, Yan-bin; Gong, Feng, Huaihai Gongxueyuan Xuebao, 2007, 16(2), 36-39

合成路线：1 步

74-96-4

_92%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide

参考文献：

Synthesis of sedative-hypnotic zaleplon

Ren, Jin-Zhi; Wang, Zhao-Hui, Zhongguo Yaoke Daxue Xuebao, 2000, 31(6), 474-476

合成路线：1 步

_91%

反应条件：

1.1 5 h, reflux

参考文献：

Method for synthesis of zaleplon (N-(3-(3-cyanopyrazolo[1,5-α]pyrimidin-7-yl)phenyl)-N-ethylacetamide) for treating insomnia

, China, , ,

合成路线：1 步

74-96-4

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 5 h, rt

参考文献：

Improvement on the synthetic technology of zaleplon as a new sedative and hypnotic drug

Zheng, Lianyou; Wang, Songqing; Li, Bingchao; Sun, Weijun, Zhongguo Yaowu Huaxue Zazhi, 2001, 11(6), 353-355

合成路线：1 步

74-96-4

_82%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0.5 h, 40 °C
1.2 5 h, 50 °C
1.3 Solvents: Water ; 0.5 h, 0 °C; overnight

参考文献：

Synthesis of zaleplon

Shen, Jingshan; Li, Jianfeng; Li, Fei; Wei, Min; Ji, Ruyun, Zhongguo Yiyao Gongye Zazhi, 2002, 33(7), 313-314

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 30 min, rt; rt → 0 °C
1.2 Solvents: Dimethylformamide ; 0 °C; 1 h, rt

参考文献：

Immunodetection and quantification of pyrazolopyrimidine sedatives

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Solvents: Dimethylformamide ; 15 min, 25 - 35 °C; 35 °C → 25 °C; 20 - 25 °C; 1 h, 20 - 25 °C; 25 °C → 0 °C
1.2 Solvents: Dimethylformamide ; 1 - 2 h, 0 - 5 °C; 15 min, 0 - 5 °C; 5 °C → 25 °C; 3 h, 20 - 25 °C

参考文献：

An improved process for the preparation of Zaleplon

, India, , ,

合成路线：1 步

64-67-5

反应条件：

1.1 Reagents: Potassium hydroxide , Tetrabutylammonium bromide Solvents: Dimethyl sulfoxide ; 30 ± 5 °C; 30 °C → 12 °C; < 20 °C; 3 h, 30 ± 2 °C

参考文献：

Process for the preparation of zaleplon and an intermediate thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

96605-68-4

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0.5 h, rt; cooled
1.2 Solvents: Dimethylformamide ; 0.5 h, rt

参考文献：

Preparation of substituted pyrazolo(1,5-a)pyrimidines for use as anxiolytics

, United States, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Dimethylformamide ; 1 h; 6 h
1.2 Reagents: Water

参考文献：

Zaleplon synthesis

, World Intellectual Property Organization, , ,

合成路线：1 步

参考文献：

Immunodetection and quantification of pyrazolopyrimidine sedatives

, United States, , ,

合成路线：1 步

参考文献：

A process for producing zaleplon

, India, , ,

合成路线：1 步

参考文献：

One-pot method for obtaining N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide

, United States, , ,

合成路线：1 步