97415-09-3 (D-(-)-扁桃酸苄酯,D-(-)-Mandelic Acid Benzyl Ester)

_93%

反应条件：

1.1 Catalysts: Sodium carbonate , Iron(III) acetylacetonate Solvents: Heptane ; rt → 105 °C; 7 h, 105 °C; 105 °C → rt
1.2 Reagents: Ammonium chloride Solvents: Water

参考文献：

Transesterification catalyzed by iron(III) β-diketonate species

Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying, Tetrahedron, 2011, 67(9), 1640-1648

合成路线：1 步

20698-91-3

_91%

反应条件：

1.1 Catalysts: Lanthanum nitrate , Phosphonium, methyltrioctyl-, methyl carbonate (1:1) Solvents: Hexane ; 5 min, rt
1.2 3 h, 90 °C; 90 °C → rt
1.3 Reagents: Water ; 5 min, rt

参考文献：

In situ generated "lanthanum(III) nitrate alkoxide" as a highly active and nearly neutral transesterification catalyst

Hatano, Manabu; Kamiya, Sho; Ishihara, Kazuaki, Chemical Communications (Cambridge, 2012, 48(76), 9465-9467

合成路线：1 步

_91%

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Benzene

参考文献：

Preparation of arylacetic acid monoesters as intermediates for prostaglandins and other natural products

, European Patent Organization, , ,

合成路线：1 步

100-39-0

_88%

反应条件：

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ; overnight, rt

参考文献：

Preparation of amino acid derivatives for use as thrombin inhibitors

, United States, , ,

合成路线：1 步

100-39-0

_87%

反应条件：

1.1 Catalysts: Potassium carbonate Solvents: Dimethylformamide ; 2 h, rt

参考文献：

Preparation of optically active condensation products of optically active aromatic hydroxycarboxylic acids

, Japan, , ,

合成路线：1 步

_41%

反应条件：

1.1 Reagents: p-Toluenesulfonic acid Solvents: Benzene
1.2 Solvents: Dichloromethane

参考文献：

Expanding the utility of proteases in synthesis: broadening the substrate acceptance in non-coded amide bond formation using chemically modified mutants of subtilisin

Khumtaveeporn, K.; Ullmann, A.; Matsumoto, K.; Davis, B. G.; Jones, J. B., Tetrahedron: Asymmetry, 2001, 12(2), 249-261

合成路线：1 步

17199-29-0

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Cyclohexane ; 25 - 35 °C; 35 °C → 82 °C; 26 h, 80 - 82 °C

参考文献：

An improved process for preparing optically active phosphate esters as intermediate for HMG-CoA reductase inhibitors

, India, , ,

合成路线：1 步

参考文献：

Preparation of amino acid derivatives as thrombin inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

参考文献：

Optically active polyamides having an (-)-anti head-to-head coumarin dimer component. 3. Chiral recognition ability

Chen, Yun; Saigo, Kazuhiko; Yonezawa, Noriyuki; Tachibana, Kouzou; Hasegawa, Masaki, Bulletin of the Chemical Society of Japan, 1987, 60(9), 3341-5

合成路线：1 步

反应条件：

1.1 Reagents: Oxygen Catalysts: (OC-6-53)-[N-[[3-(1,1-Dimethylethyl)-2-(hydroxy-κO)-5-(1H-1,2,3-triazol-5-ylmeth… (polystyrene-supported) Solvents: Chloroform ; 34 h, rt

参考文献：

Asymmetric Aerobic Oxidation of α-Hydroxy Acid Derivatives Catalyzed by Reusable, Polystyrene-Supported Chiral N-Salicylidene Oxidovanadium tert-Leucinates

Salunke, Santosh B.; Babu, N. Seshu; Chen, Chien-Tien, Advanced Synthesis & Catalysis, 2011, 353(8), 1234-1240

合成路线：1 步

反应条件：

1.1 Catalysts: Scandium triflate , 1799512-71-2 Solvents: Tetrahydrofuran ; 30 min, 35 °C; 35 °C → 0 °C
1.2 48 h, 0 °C

参考文献：

Kinetic Resolution of Racemic Mandelic Acid Esters by N,N'-Dioxide-Scandium-Complex-Catalyzed Enantiomer-Selective Acylation

Zhang, Yuheng; Liu, Xiaohua; Zhou, Lin; Wu, Wangbin; Huang, Tianyu; et al, Chemistry - A European Journal, 2014, 20(48), 15884-15890

合成路线：1 步

反应条件：

1.1 Reagents: Oxygen Catalysts: (OC-6-53)-[N-[[3-(1,1-Dimethylethyl)-2-(hydroxy-κO)-5-nitrophenyl]methylene]-3-m… Solvents: Toluene ; 15 s, 15 torr, rt
1.2 Reagents: Oxygen Solvents: Toluene ; 14.5 h, rt

参考文献：

Asymmetric Aerobic Oxidation of α-Hydroxy Acid Derivatives by C4-Symmetric, Vanadate-Centered, Tetrakisvanadyl(V) Clusters Derived from N-Salicylidene-α-aminocarboxylates

Chen, Chien-Tien; Bettigeri, Sampada; Weng, Shiue-Shien; Pawar, Vijay D.; Lin, Ya-Hui; et al, Journal of Organic Chemistry, 2007, 72(22), 8175-8185

合成路线：1 步

反应条件：

1.1 Reagents: Oxygen Catalysts: (OC-6-53)-[N-[[3-(1,1-Dimethylethyl)-2-(hydroxy-κO)-5-nitrophenyl]methylene]-3-m… Solvents: Toluene ; 14.5 h, rt
1.2 Reagents: Water

参考文献：

Chiral N-salicylidene vanadyl carboxylate-catalyzed enantioselective aerobic oxidation of α-hydroxy esters and amides

Weng, Shiue-Shien; Shen, Mei-Wen; Kao, Jun-Qi; Munot, Yogesh S.; Chen, Chien-Tien, Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(10), 3522-3527

合成路线：1 步