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  4. 抗氧剂 1222 | 976-56-7

976-56-7 (抗氧剂 1222,Diethyl (3,5-Di-tert-butyl-4-hydroxybenzyl)phosphonate)

快速询单
结构式：
抗氧剂 1222结构式图片|976-56-7结构式图片
抗氧剂 1222MOL文件
CAS号：
976-56-7
中文名称：
抗氧剂 1222
英文名称：
Diethyl (3,5-Di-tert-butyl-4-hydroxybenzyl)phosphonate
分子式：
C19H33O4P
分子量：
356.436687231064
相关分类：
溶剂及有机化学品 > 有机化合物 > 醇/醚类
苯酚

抗氧剂 1222(976-56-7)名称与标识符

名称

中文别名：
抗氧剂 1222;3,5-二叔丁基-4-羟基苄基二乙基膦酸酯;3,5-二叔丁基-4-羟基苯甲基磷酸二乙酯;4-氯磺酰基苯甲酸乙酯;Diethyl 3,5-Di-tert-butyl-4-hydroxybenzylphosphonate 3,5-二叔丁基-4-羟基苯甲基磷酸二乙酯;磷酸-(3,5-二叔丁基-4-羟基苄基)二乙酯;
英文别名：
Diethyl 3,5-di-tert-butyl-4-hydroxybenzyl phosphate;Antioxidant 1222;Diethyl 3,5-Di-tert-butyl-4-hydroxybenzylphosphonate;3,5-di-tert-butyl-4-hydroxybenzyl-phosphonic acid diethyl ester;4-Hydroxy-3.5-di-tert.-butyl-phenyl-methan-phosphonsaeurediethylester;Diethyl ((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methyl)phosphonate;diethyl (3,5-di-tert-butyl-4-hydroxyphenyl)methanephosphonate;diethyl 4-hydroxy-3,5-di-tert-butylbenzylphosphonate;EINECS 213-551-9;O,O-diethyl (3,5-ditert-butyl-4-hydroxybenzyl)phosphonate;Phosphonic acid,[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-,diethyl ester;3,5-Di-tert-butyl-4-hydroxybenzylphosphonic Acid Diethyl Ester;Diethyl P-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate (ACI);Phosphonic acid, (3,5-di-tert-butyl-4-hydroxybenzyl)-, diethyl ester (7CI, 8CI);Phosphonic acid, [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-, diethyl ester (9CI);(3,5-Di-tert-butyl-4-hydroxy-benzyl)-phosphonic acid diethyl ester;Antioxidant 122;Diethyl (3,5-di-tert-butyl-4-hydroxybenzyl)phosphonate;Diethyl [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate;Heat Stabilizer 3114;Irgamod 295;Irganox 1222;NSC 635180;P-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylphosphonic acid diethyl ester;976-56-7;Phosphonic acid, ((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methyl)-, diethyl ester;NSC-635180;NSC635180;MFCD00227871;SCHEMBL39364;Phosphonic acid, P-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methyl)-, diethyl ester;D2967;diethyl 3,5-di-t-butyl-4-hydroxybenzylphosphonate;BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL)METHYL)PHOSPHONIC ACID DIETHYL ESTER, ((3,5-;Q27291597;DTXSID7061356;diethyl (3,5-di-tert-butyl-4-hydroxyphenyl)methylphosphonate;SR-01000402272-1;V6MOU97T5J;3,5-di-tert. butyl-4-hydroxybenzyl-phosphonic acid diethyl ester;EU-0001821;SR-01000402272;Heat Stabilizer 3114; Irgamod 295; NSC 635180;H10954;W-109624;DB-057681;NS00015579;STK365464;diethyl [(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]phosphonate;Phosphonic acid, [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]-, diethyl ester;Diethyl [[3,5-dis(1,1-dimethylethyl)-4-OHphenyl]methyl]phosphonate;(3,5-ditert-butyl-4-hydroxy-phenyl)methyl diethyl phosphate;Diethyl 35-Di-tert-butyl-4-hydroxybenzylphosphonate;AS-70580;2,6-ditert-butyl-4-(diethoxyphosphorylmethyl)phenol;AKOS004912739;UNII-V6MOU97T5J;Diethyl3,5-di-tert-butyl-4-hydroxybenzylphosphonate;

标识符

MDL：
MFCD00227871
InChIKey：
GJDRKHHGPHLVNI-UHFFFAOYSA-N
Inchi：
1S/C19H33O4P/c1-9-22-24(21,23-10-2)13-14-11-15(18(3,4)5)17(20)16(12-14)19(6,7)8/h11-12,20H,9-10,13H2,1-8H3
SMILES：
O=P(CC1C=C(C(C)(C)C)C(O)=C(C(C)(C)C)C=1)(OCC)OCC

抗氧剂 1222(976-56-7)物化性质

实验特性

  • LogP : 5.75330
  • PSA : 65.57000
  • 熔点 : 120.0 to 124.0 deg-C
  • 颜色与性状 : 白色或微黄色结晶性粉末。
  • 溶解性 : 微溶于水，20℃时在100ml下列溶剂中的溶解克数为

计算特性

  • 精确分子量 : 356.21200
  • 氢键供体数量 : 1
  • 氢键受体数量 : 4
  • 可旋转化学键数量 : 8
  • 同位素质量 : 356.21164653g/mol
  • 重原子数量 : 24
  • 复杂度 : 402
  • 同位素原子数量 : 0
  • 确定原子立构中心数量 : 0
  • 不确定原子立构中心数量 : 0
  • 确定化学键立构中心数量 : 0
  • 不确定化学键立构中心数量 : 0
  • 共价键单元数量 : 1
  • 疏水参数计算参考值（XlogP） : 4.7
  • 互变异构体数量 : 2
  • 表面电荷 : 0
  • 拓扑分子极性表面积 : 55.8Ų

抗氧剂 1222(976-56-7)安全信息

抗氧剂 1222(976-56-7)国际标准相关数据

EINECS：
213-551-9

抗氧剂 1222(976-56-7)推荐厂家 更多厂家(59)

公司名称手机号/电话联系人QQ微信询单
湖北健楚生物医药有限公司 13477033894
027-65528557		陈经理 3821225285
询单
湖北万得化工有限公司 15827180502
027-59210159		陈丹丹 1148980033
询单
湖北巨胜科技有限公司 18871490354王珊 1400848866
询单
湖北摆渡化学有限公司 18871490324
027-59106051		彭星 1400878899
询单
湖北方德新材料有限公司 18086096695邱经理 1462312301
询单
江苏永健医药科技有限公司 17701422016韩经理 3587493084
询单
武汉欣欣佳丽生物科技有限公司 13207195831
027-84666270		王经理 1961290147
询单
广东翁江化学试剂有限公司 13927875076
0751-2815987		罗雪云 3007432263
询单
铼博（上海）生化科技有限公司 13311756052
021-60536361 13311756052 13311756131		张经理 2851717387
询单
铼博（上海）生化科技有限公司 13311756052
021-60536361 13311756052 13311756131		张经理 2851717387
询单

抗氧剂 1222(976-56-7)合成路线

合成路线：1 步
955-01-1
122-52-1
99%
976-56-7
反应条件：
参考文献：
1,1- And 1,2-bisphosphonates as apolipoprotein E modulators and therapeutic uses for treatment of cardiovascular and neurol. diseases
, World Intellectual Property Organization, , ,
合成路线：1 步
128-39-2
50-00-0
122-52-1
94%
976-56-7
反应条件：
参考文献：
Process for preparation of sterically hindered hydroxybenzylphosphonates
, European Patent Organization, , ,
合成路线：1 步
794-53-6
762-04-9
94%
976-56-7
参考文献：
Cyclic organophosphorus compounds with an active methyl group. II. Synthesis and some transformations of 3,5-di-tert-butyl-4-hydroxybenzylcyclophosphonates
Ovchinnikov, V. V.; Cherkasova, O. A.; Mukmeneva, N. A.; Liakumovich, A. G.; Pudovik, A. N., Zhurnal Obshchei Khimii, 1981, 51(5), 999-1002
合成路线：1 步
128-39-2
50-00-0
762-04-9
88%
976-56-7
反应条件：
参考文献：
Preparation of substituted benzylphosphonate esters as resin antioxidants
, Japan, , ,
合成路线：1 步
128-39-2
50-00-0
122-52-1
86%
976-56-7
反应条件：
参考文献：
Preparation of substituted benzylphosphonate esters as antioxidants for resins
, Japan, , ,
合成路线：1 步
122-52-1
88-27-7
78%
976-56-7
反应条件：
参考文献：
Preparation of benzylphosphonates from benzylamines and trialkyl phosphites
, Japan, , ,
合成路线：1 步
51917-73-8
122-52-1
74%
976-56-7
参考文献：
Synthesis and properties of phosphorylated 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadiene-1-ones
Ismagilov, R. K.; Moskva, V. V.; Arkhipov, V. P.; Ivantsov, A. E.; Kopylova, L. Yu., Zhurnal Obshchei Khimii, 1991, 61(2), 387-91
合成路线：1 步
955-01-1
122-52-1
73%
976-56-7
参考文献：
Synthesis and ESR spectra of persistent aroxyls. III. Dialkyl 3,5-di-t-butyl-4-hydroxybenzylphosphonates and their corresponding aroxyls
Herdan, Jean M.; Negoita, Nicolae; Grecu, Maria Nicoleta; Gheorghiu, Mircea D.; Balaban, Alexandru T., Revue Roumaine de Chimie, 1989, 34(7), 1515-21
合成路线：1 步
128-39-2
122-52-1
50-00-0
65%
976-56-7
反应条件：
参考文献：
Preparation of [(hydroxyphenyl)methyl]phosphonates by reaction of phenol with formaldehyde and a phosphite
, European Patent Organization, , ,
合成路线：1 步
762-04-9
128-37-0
10%
976-56-7
反应条件：
参考文献：
Copper-catalyzed three-component phosphorylation-peroxidation of alkenes
Chen, Yan; Chen, Yuanjin; Lu, Shenglin; Li, Zhiping, Organic Chemistry Frontiers, 2018, 5(6), 972-976
合成路线：1 步
2091-51-2
122-52-1
976-56-7
参考文献：
Optical component comprising waveguide and quantum confined semiconductor nanoparticles
, United States, , ,
合成路线：1 步
2091-51-2
122-52-1
976-56-7
参考文献：
Quantum confined semiconductor nanocrystals useful to separate light source without crosstalk
, World Intellectual Property Organization, , ,
合成路线：1 步
2091-51-2
122-52-1
976-56-7
参考文献：
Nanoparticle including multi-functional ligand and method
, World Intellectual Property Organization, , ,
合成路线：1 步
2091-51-2
122-52-1
976-56-7
参考文献：
Solid state lighting devices including quantum confined semiconductor nanoparticles
, World Intellectual Property Organization, , ,
合成路线：1 步
128893-72-1
976-56-7
60367-10-4
反应条件：
参考文献：
α-Diethoxyphosphoryl-2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone: reduction and formation
Ismagilov, R. K.; Moskva, V. V.; Kuz'min, V. K., Zhurnal Obshchei Khimii, 1995, 65(9), 1477-8
合成路线：1 步
762-04-9
88-27-7
976-56-7
118-82-1
反应条件：
参考文献：
Production process of antioxidant 1425
, China, , ,

抗氧剂 1222(976-56-7)参考资料

Reaxys RN：
2949149
Beilstein：
D155510
PubChem CID：
87569321

抗氧剂 1222(976-56-7) MSDS

基础信息

  Diethyl 3,5-Di-tert-butyl-4-hydroxybenzylphosphonate Revision number: 5
  SAFETY DATA SHEET
Section 1. IDENTIFICATION
  Product name:        Diethyl 3,5-Di-tert-butyl-4-hydroxybenzylphosphonate    
    
  Revision number:        5    
Section 2. HAZARDS IDENTIFICATION
  GHS classification
  PHYSICAL HAZARDS        Not classified    
    Not classified
  HEALTH HAZARDS
  ENVIRONMENTAL HAZARDS        Not classified    
  GHS label elements, including precautionary statements
  Pictograms or hazard symbols        None    
    No signal word
  Signal word
  Hazard statements        None    
    None
  Precautionary statements:
Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
  Substance/mixture:        Substance    
  Components:        Diethyl 3,5-Di-tert-butyl-4-hydroxybenzylphosphonate    
  Percent:        >98.0%(LC)    
  CAS Number:        976-56-7    
  Synonyms:        3,5-Di-tert-butyl-4-hydroxybenzylphosphonic Acid Diethyl Ester    
  Chemical Formula:        C19H33O4P    
Section 4. FIRST AID MEASURES
  Inhalation:        Remove victim to fresh air and keep at rest in a position comfortable for breathing.    
    Get medical advice/attention if you feel unwell.
  Skin contact:        Remove/Take off immediately all contaminated clothing. Rinse skin with    
    water/shower. If skin irritation or rash occurs: Get medical advice/attention.
  Eye contact:        Rinse cautiously with water for several minutes. Remove contact lenses, if present    
    and easy to do. Continue rinsing. If eye irritation persists: Get medical
    advice/attention.
  Ingestion:        Get medical advice/attention if you feel unwell. Rinse mouth.    
  Protection of first-aiders:        A rescuer should wear personal protective equipment, such as rubber gloves and air-    
    tight goggles.
Section 5. FIRE-FIGHTING MEASURES
  Suitable extinguishing        Dry chemical, foam, water spray, carbon dioxide.    
  media:
  Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
  from the chemical:        generate poisonous fume.    
  Diethyl 3,5-Di-tert-butyl-4-
  hydroxybenzylphosphonate
Section 5. FIRE-FIGHTING MEASURES
  Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
    method according to the surrounding situation is used. Uninvolved persons should
    evacuate to a safe place. In case of fire in the surroundings: Remove movable
    containers if safe to do so.
  Special protective        When extinguishing fire, be sure to wear personal protective equipment.    
  equipment for firefighters:
Section 6. ACCIDENTAL RELEASE MEASURES
    Use personal protective equipment. Keep people away from and upwind of spill/leak.
  Personal precautions,
  protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
  emergency procedures: roping off, etc.
  Environmental precautions: Prevent product from entering drains.
  Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
  containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
  up: appropriate laws and regulations.
Section 7. HANDLING AND STORAGE
  Precautions for safe handling
    Handling is performed in a well ventilated place. Wear suitable protective equipment.
  Technical measures:
    Prevent dispersion of dust. Wash hands and face thoroughly after handling.
    Use a local exhaust if dust or aerosol will be generated.
  Advice on safe handling: Avoid contact with skin, eyes and clothing.
  Conditions for safe storage, including any
  incompatibilities
  Storage conditions:        Keep container tightly closed. Store in a cool and dark place.    
    Store away from incompatible materials such as oxidizing agents.
  Packaging material:        Comply with laws.    
Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
    Install a closed system or local exhaust as possible so that workers should not be
  Engineering controls:
    exposed directly. Also install safety shower and eye bath.
  Personal protective equipment
  Respiratory protection: Dust respirator. Follow local and national regulations.
  Hand protection:        Protective gloves.    
  Eye protection:        Safety glasses. A face-shield, if the situation requires.    
  Skin and body protection: Protective clothing. Protective boots, if the situation requires.
Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Physical state (20°C):        Solid    
  Form:        Crystal- Powder    
    White - Almost white
  Colour:
  Odour:        No data available    
  pH: No data available
  Melting point/freezing point:122°C
    No data available
  Boiling point/range:
  Flash point:        No data available    
  Flammability or explosive
  limits:
    No data available
  Lower:
  Upper:        No data available    
    No data available
  Relative density:
  Solubility(ies):
    No data available
  [Water]
  [Other solvents]
    Methanol
  Soluble:
  Diethyl 3,5-Di-tert-butyl-4-
  hydroxybenzylphosphonate
Section 10. STABILITY AND REACTIVITY
  Chemical stability:        Stable under proper conditions.    
  Possibility of hazardous No special reactivity has been reported.
  reactions:
  Incompatible materials: Oxidizing agents
  Hazardous decomposition Carbon monoxide, Carbon dioxide, Phosphorus oxides
  products:
Section 11. TOXICOLOGICAL INFORMATION
    No data available
  Acute Toxicity:
  Skin corrosion/irritation: No data available
    No data available
  Serious eye
  damage/irritation:
  Germ cell mutagenicity: No data available
  Carcinogenicity:
    No data available
  IARC =
  NTP =        No data available    
    No data available
  Reproductive toxicity:
Section 12. ECOLOGICAL INFORMATION
  Ecotoxicity:
  Fish:        No data available    
  Crustacea:        No data available    
  Algae:        No data available    
  Persistence / degradability: No data available
  Bioaccumulative        No data available    
  potential(BCF):
  Mobility in soil
  Log Pow:        No data available    
  Soil adsorption (Koc):        No data available    
  Henry's Law        No data available    
  constant(PaM3/mol):
Section 13. DISPOSAL CONSIDERATIONS
    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
    Observe all federal, state and local regulations when disposing of the substance.
Section 14. TRANSPORT INFORMATION
  Hazards Class:        Does not correspond to the classification standard of the United Nations    
  UN-No:        Not listed    
Section 15. REGULATORY INFORMATION
  Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
  and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
    loading and unloading were prescribed.
  Diethyl 3,5-Di-tert-butyl-4-
  hydroxybenzylphosphonate

SECTION 16 - ADDITIONAL INFORMATION
N/A

目录

1.基本信息 2.名称与标识符 2.1.名称 2.2.标识符 3.物化性质 3.1.实验特性 3.2.计算特性 4.安全信息 5.国际标准相关数据 6.推荐厂家 7.合成路线 8.参考资料 9.抗氧剂 1222 MSDS
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