97966-29-5 (异阿魏酸甲酯,(2E)-3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic Acid Methyl Ester)

_97%

反应条件：

1.1 Solvents: Dichloromethane ; 16 h, rt; 2 h, rt → reflux

参考文献：

Optical Control of TRPV1 Channels

Stein, Marco; Breit, Andreas; Fehrentz, Timm; Gudermann, Thomas; Trauner, Dirk, Angewandte Chemie, 2013, 52(37), 9845-9848

合成路线：1 步

537-73-5

_91%

反应条件：

1.1 Catalysts: Sulfuric acid ; 4 h, reflux

参考文献：

Search for novel histone deacetylase inhibitors. Part II: Design and synthesis of novel isoferulic acid derivatives

Lu, Wen; Wang, Fang; Zhang, Tao; Dong, Jinyun; Gao, Hongping; et al, Bioorganic & Medicinal Chemistry, 2014, 22(9), 2707-2713

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Triphenylphosphine , Iodine Solvents: Acetonitrile ; 10 min, rt
1.2 Catalysts: Zinc triflate ; 30 min, 60 °C
1.3 Solvents: Acetonitrile ; 3.5 h, 60 °C

参考文献：

Zn(OTf)2-Promoted Chemoselective Esterification of Hydroxyl Group Bearing Carboxylic Acids

Mamidi, Narsimha; Manna, Debasis, Journal of Organic Chemistry, 2013, 78(6), 2386-2396

合成路线：1 步

48200-25-5

_90%

反应条件：

1.1 Solvents: Benzene

参考文献：

Syntheses of Certain 3-Aryl-2-propenoates and Evaluation of their Cytotoxicity

Nam, N.-H.; You, Y.-J.; Kim, Y.; Hong, D.-H.; Kim, H.-M.; et al, Bioorganic & Medicinal Chemistry Letters, 2001, 11(9), 1173-1176

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Boron trifluoride etherate ; 12 h, 0 °C → rt

参考文献：

Purification and biochemical characterization of feruloyl esterases from Aspergillus terreus MTCC 11096

Kumar, C. Ganesh; Kamle, Avijeet; Kamal, Ahmed, Biotechnology Progress, 2013, 29(4), 924-932

合成路线：1 步

_84%

反应条件：

1.1 Catalysts: Sulfuric acid Solvents: Methanol ; 3 h, reflux

参考文献：

Synthetic Guaiacol Derivatives as Promising Myeloperoxidase Inhibitors Targeting Atherosclerotic Cardiovascular Disease

Premkumar, Jayaraj ; Sampath, Parthasarathy; Sanjay, Rajagopalan; Chandrakala, Aluganti; Rajagopal, Desikan, ChemMedChem, 2020, 15(13), 1187-1199

合成路线：1 步

2605-67-6

_78%

反应条件：

1.1 3 min

参考文献：

Convenient microwave assisted synthesis of naturally occurring methyl (E)-cinnamates

Mahajan, Rajesh P.; Patil, Shamkant L.; Mali, Raghao S., Organic Preparations and Procedures International, 2005, 37(3), 286-290

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Thionyl chloride Solvents: Dichloromethane ; 0.5 h, rt; rt → reflux; 2 h, reflux
1.2 Solvents: Dichloromethane ; 1 h, reflux; 3 h, reflux

参考文献：

Inhibitory effects of substituted cinnamic acid esters on mushroom tyrosinase

Zhang, Zhenghua; Liu, Jinbing; Wu, Fengyan; Zhao, Liangzhong, Letters in Drug Design & Discovery, 2013, 10(6), 529-534

合成路线：1 步

762-42-5

_60%

反应条件：

1.1 Catalysts: Triphenylphosphine Solvents: Dichloromethane ; 10 min, -10 °C; 24 h, rt

参考文献：

Triphenylphosphine-mediated serendipitous synthesis of alkyl cinnamates through the reaction of 3-hydroxy-4-methoxybenzaldehyde with dialkyl acetylenedicarboxylates

Yavari, Issa; Djahaniani, Hoorieh; Moradi, Logman; Nasiri, Farough, Phosphorus, 2005, 180(9), 2149-2153

合成路线：1 步

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Methanol ; rt; 16 h, reflux

参考文献：

Cage-confined photocatalysis for wide-scope unusually selective [2 + 2] cycloaddition through visible-light triplet sensitization

Wang, Jing-Si; Wu, Kai ; Yin, Changzhen; Li, Kang; Huang, Yahao; et al, Nature Communications, 2020, 11(1),

合成路线：1 步

反应条件：

1.1 Reagents: Thionyl chloride Solvents: Methanol ; 2 h, rt

参考文献：

Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect

Zhang, Wen-Xi; Wang, Hui; Cui, He-Rong; Guo, Wen-Bo; Zhou, Fei; et al, European Journal of Medicinal Chemistry, 2019, 183,

合成路线：1 步

反应条件：

1.1 Catalysts: Sulfuric acid Solvents: Methanol ; 12 h, 70 °C; cooled
1.2 Reagents: Sodium carbonate Solvents: Water ; pH 7

参考文献：

Design, synthesis and antitumor evaluation of novel celastrol derivatives

Xu, Manyi; Li, Na; Zhao, Zihao; Shi, Zhixian; Sun, Jianbo; et al, European Journal of Medicinal Chemistry, 2019, 174, 265-276

合成路线：1 步

反应条件：

1.1 Catalysts: Sulfuric acid Solvents: Methanol ; 12 h, reflux

参考文献：

Synthesis and anticancer activities of glycyrrhetinic acid derivatives

Li, Yang; Feng, Ling; Song, Zhi-Fang; Li, Hai-Bei; Huai, Qi-Yong, Molecules, 2016, 21(2),

合成路线：1 步

108-59-8

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid , Dimethylformamide dimethyl acetal Solvents: Toluene ; 16 h, reflux

参考文献：

Catalytic enamines from dialkylamide-dialkylacetals

Davey, Roger M.; Stamford, N. Patrick J., Tetrahedron Letters, 2012, 53(20), 2537-2539

合成路线：1 步

96-32-2