UF010

中文名：UF010

英文名：UF010

纯度：≥96%

货号：U413338

Cas号：537672-41-6

存储温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：

Information

UF010 is a class I HDAC-selective inhibitor with IC50 values of 0.5 nM, 0.1 nM, 0.06 nM, 1.5 nM, 9.1 nM and 15.3 nM for HDAC1, HDAC2, HDAC3, HDAC8, HDAC6 and HDAC10, respectively.

Targets

HDAC3 (Cell-free assay); HDAC2 (Cell-free assay); HDAC1 (Cell-free assay); HDAC8 (Cell-free assay); HDAC6 (Cell-free assay) 31045,0.06 nM; 0.1 nM; 0.5 nM; 1.5 nM; 9.1 nM

In vitro

In Cell-cycle analysis using MDA-MB-231 cells, UF010 mainly blocks G1/S transition with an increased G1 cell population and a reduced cell population in the S phase in a dose-dependent manner. UF010 has a half-life of 15.8 hr in cell culture medium containing 10% fetal bovine serum.

Cell Research(from reference)

Cell lines：HCT116 cells and A549 cells

Concentrations：2 μM

Incubation Time：1 h

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