2-巯基吡啶-N-氧化物 锌盐

中文名：2-巯基吡啶-N-氧化物 锌盐

英文名：Zinc Pyrithione

纯度：Moligand™，10mM in DMSO

货号：Z408773

Cas号：13463-41-7

存储温度：-80℃储存

运输条件：超低温冰袋运输

产品介绍：

Information

Zinc Pyrithione Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump .
In vitro

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn ²⁺ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K_1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential.

In vivo

Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50)\u2009= 8.27\u2009μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

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