| 中文名称： | 曲妥珠单抗 | 中文别名： | 曲妥珠单抗 |
|---|---|---|---|
| 英文名称： | Trastuzumab | CAS： | 180288-69-1 |
| 产品分类： | 纯度： | 99% |
| 产品编号 | 品牌 | 纯度 | 规格 | 库存 | 价格 |
|---|---|---|---|---|---|
| R13951 | 瑞威尔 | 99% | R13951-10ml | 99 | 2,500.00 元 |
| R13951 | 瑞威尔 | 99% | R13951-50ml | 99 | 6,000.00 元 |
| R13951 | 瑞威尔 | 99% | R13951-1g | 99 | 12,000.00 元 |
| 标准名称: | 曲妥珠单抗 | 英文名称： | Trastuzumab |
|---|---|---|---|
| CAS： | 180288-69-1 | 分子式： | 0 |
| 分子量： | 298.26 | 颜色与性状： | |
| 密度： | 沸点： | ||
| 熔点： | 水溶性： |
江西瑞威尔生物，利福系列，单抗系列，替加系列
曲妥珠单抗生物活性
描述 曲妥珠单抗(PBS)是一种人源化IgG1单克隆抗体,用于过度表达HER2的侵袭性乳腺癌患者。曲妥珠单抗(PBS)具有HER2阳性转移性癌症和HER2阳性癌症研究的潜力。
相关类别
研究领域 >> 癌症
信号通路 >> JAK/STAT信号通路 >> EGFR
信号通路 >> 蛋白酪氨酸激酶 >> EGFR
体外研究 用 曲妥珠单抗处理过表达 HER2的乳腺癌细胞系会导致 p27KIP1和 Rb相关蛋白 p130的诱导,从而显著减少经历 S期的细胞数量。由于 曲妥珠单抗与 HER2过表达细胞结合,在体外观察到许多其他表型变化。曲妥珠单抗通过其人免疫球蛋白 G1 Fc结构域与人体免疫系统相互作用可能会增强其抗肿瘤活性。体外研究表明,曲妥珠单抗在介导抗体依赖性细胞介导的针对 HER2过表达肿瘤靶标的细胞毒性方面非常有效[1] 曲妥珠单抗由两个抗原特异性位点组成,它们结合 HER2受体胞外结构域的近膜部分,并阻止其胞内酪氨酸激酶的激活。曲妥珠单抗募集负责抗体依赖性细胞毒性的免疫效应细胞[2] 曲妥珠单抗IgG的存在显著增加了对所有乳腺癌细胞系的杀伤力。曲妥珠单抗诱发的 PBMC的 ADCC活性对 曲妥珠单抗敏感 (SKBR-3)或 曲妥珠单抗耐药 (JIMT-1)乳腺癌细胞同样很强,剂量依赖性细胞死亡在效应物/靶标处达到 50-60%杀死比例为 60:1[3]
体内研究 小鼠异种移植模型的 曲妥珠单抗处理可显著抑制肿瘤生长。当与标准细胞毒性化疗药物联合使用时,曲妥珠单抗处理与单独使用任一药物相比通常具有统计学上更好的抗肿瘤疗效[1] 曲妥珠单抗可显著抑制裸鼠和 SCID小鼠肉眼可见的 JIMT-1异种移植肿瘤的生长[3]
参考文献
[1]. Sliwkowski MX, et al. Nonclinical studies addressing the mechanism of action of trastuzumab. Semin Oncol. 1999 Aug;26(4 Suppl 12):60-70.
[2]. Hudis CA, et al. Trastuzumab--mechanism of action and use in clinical practice. N Engl J Med. 2007 Jul 5;357(1):39-51.
[3]. Barok M, et al. Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance. Mol Cancer Ther. 2007 Jul;6(7):2065-72.
曲妥珠单抗物理化学性质
分子式 C6470H10012N1726O2013S42
分子量 145531.50
储存条件 -20℃，避光
曲妥珠单抗英文别名
Herceptin
Jiangxi Ruiwell Biotechnology Co., Ltd. is located in Xiajiang County, Jiangxi Province, deeply engaged in the field of scientific research reagents. Can provide customers with general chemical reagents, high purity reagents, environmental protection reagents, reference reagents, biochemical reagents, analytical standard solution, impurity determination standard solution and buffer solution, fine chemicals, catalysts, scientific research excipients, intermediates and fine chemicals and other more than 30,000 kinds of products. Products are widely used in colleges and universities, research institutes and biomedical, new materials, new energy, energy conservation, environmental protection, aerospace and other high-tech industries and strategic emerging industry related enterprises R & D institutions, product users are mostly scientists and front-line R & D engineers, has won the trust of many customers. The company has been selected as a national science and technology small and medium-sized enterprise, and has passed QES three system certifications (ISO9001:2015 quality management system, ISO14001:2015 Environmental quality management system certification, ISO45001:2018 Occupational health and safety management system), EU CE certification, EU REACH registration. It is now a member of China Chemical Reagent Industry Association (Pilot Association), and its products are insured by PICC. The company has been adhering to the "quality first, honest service" service concept, for the country's major universities, research institutes and other units to provide high-quality technical services. The company's business is now all over the country. Over the years, Ruiwill adhere to the customer first, integrity-based business purpose, with a strong advantage of product prices, reliable product quality, high-quality sales service, rapid speed out of the warehouse has won the trust of customers at home and abroad. We look forward to "professional, honest, efficient and caring" service, and continue to strengthen business contacts with new and old customers, work together to create mutual win.
