| 中文名称： | 三七素(10mM in DMSO，无菌) | 中文别名： | 三七素(10mM in DMSO，无菌) |
|---|---|---|---|
| 英文名称： | β-n-Oxalylamino-l-alanine(10mM in DMSO，Sterile) | CAS： | 5302-45-4 |
| 产品分类： | 小分子化合物 | 纯度： | - |
| 产品编号 | 品牌 | 纯度 | 规格 | 库存 | 价格 |
|---|---|---|---|---|---|
| IO03201 | 索莱宝 | - | 1ml | 有现货 | 970.00 元 |
| 标准名称: | 三七素 | 英文名称： | Dencichin |
|---|---|---|---|
| CAS： | 5302-45-4 | 分子式： | C5H8N2O5 |
| 分子量： | 176.127421379089 | 颜色与性状： | Powder |
| 密度： | 1.596±0.06 g/cm3 (20 ºC 760 Torr), | 沸点： | |
| 熔点： | 水溶性： |
| CAS | 5302-45-4 |
| 中文名称 | 三七素(10mM in DMSO，无菌） |
| 英文名称 | β-n-Oxalylamino-l-alanine(10mM in DMSO，Sterile) |
| 分子式 | C5H8N2O5 |
| 分子量 | 176.13 |
| 规格 | 1ml |
| 溶解性 | 请根据自己的实验要求使用。 |
| 外观(性状) | 无菌溶液 |
| 储存条件 | Stroe at -20℃，6 months. |
| 运输条件 | 冷冻运输 |
| 靶点 | HIF/HIF Prolyl-Hydroxylase |
| 通路 | HIF |
| 背景说明 | β-n-Oxalylamino-l-alanine是一种HIF-prolyl hydroxylase-2 (PHD-2) 抑制剂。 |
| 生物活性 | Dencichin is a non-protein amino acid originally extracted from Panax notoginseng， and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.[1-2] |
| In Vitro | Dencichin (β-ODAP， 10 μM， 50 μM， 100 μM and 200 μM) increases HRE expression by 1.3±0.09， 2.5±0.07， 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2[1]. Dencichin (10 μM， 100 μM， 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells， and reduces the secretion of collagen I (Col I)， collagen IV (Col IV)， and fibronectin (FN)[2]. |
| In Vivo | Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80， 160 mg/kg/day， p.o.) significantly prevents the up-regulation of TCH， TG， LDL， and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models[2]. |
| 细胞实验 | Cells are cultured in 6-well plates with glucose (LG) or high glucose control (HG) and then treated with valsartan (1.0 × 10-3 M) or Dencichin (1.0 × 10-5 M， 1.0 × 10-4 M and 1.0 × 10-3 M) for 24 h before analysing the activation of FN， Col I， and Col IV expression by ELISA and analysing MMP-9 and TIMP-1 expression by immunofluorescence. Each experiment is repeated at least three times throughout the study[2]. |
| 动物实验 | Male SD rats weighted approximately 200 ± 20 g (eight weeks old) are kept at 23 ± 2°C. The rats are randomLy allotted into two groups: normal group (n = 16) and diabetic nephropathy (DN) group (n = 60). The normal rats fed with normal diet and vehicle fall into the normal control group (NC， n = 8) and the normal rats fed with normal diet and Dencichin fall into the Dencichin control group (De C， n = 8). The rats in the diabetic group are fed the high-sugar-high-fat diet (composition: Common breeding material 54.6%， lard oil 16.9%， sucrose 14%， casein 10.2%， gunk 2.1%， maltodextrin 2.2%). Five weeks later， DN is induced by administering of 40 mg/kg STZ though intraperitoneal injection， and the normal rats are treated with vehiclecitrate buffer (0.1 M， pH 4.2). Next， the DN rats (n = 32) are assigned into four groups and oral administered with metformin hydrochloride (a positive control) at 80 mg/kg/day， (DN+Met， n = 8)， which is dissolve into distilled water to make a 2 mg/mL solution before use; vehicle control for the DN control group (DN， n = 8)， or Dencichin. The Dencichin group is divided into a high Dencichin group (160 mg/kg/day; DN+De H， n = 8) and a low Dencichin group (80 mg/kg/day; DN+De L， n = 8)， which are dissolved into distilled water to make a 5 mg/mL and 2.5 mg/mL solution before use and oral administered at the dosage once per day. Blood glucose is measured each month. 8 w after administering with Dencichin， the rats are killed[2]. |
| 数据来源文献 | [1]. Eslavath RK， et al. β-N-oxalyl-L-α， β- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. Eur J Pharmacol. 2016 Nov 15;791:405-411. [2]. Jie L， et al. Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway. Eur J Pharmacol. 2017 Oct 5;812:196-205. |
| 单位 | 瓶 |
公司拥有一批专业的研发人员，我们专注于生物产品的不断完善和创新。产品覆盖面广，品质可靠。先后开发了涵盖分子生物学、细胞生物学、免疫学、生物医学等领域的多种试剂及试剂盒。同时，索莱宝公司提供各种常规生化试剂，库存常备产品多达10000多种，可随时为广大科研工作者提供各类专业试剂。在质量方面，索莱宝谨记公司信念：质量高于一切。所有研发的产品都设有严谨的生产流程，科学的质量检测方法和成熟的质量检测程序，我们恪守对每一位用户的承诺：用专业的态度做专业的品牌。同时，公司组建了一支专业的技术服务队伍，能够为科研工作者提供专业的技术服务。每一位购买索莱宝产品的用户都能够得到专业的咨询和完善的售后服务。
索莱宝公司坚持与国际接轨，注重和国际先进企业的合作与交流，并提供产品代理、市场咨询等多项服务。公司将一如既往与世界更多知名品牌合作，不断为广大生物科研工作者提供更优质的产品和服务。公司理念：“为科研服务，为生命尽责”。一个人能够走多远，取决于与谁同行。索莱宝公司期待与各同行精诚合作。
索莱宝诚招生物试剂研发人员，期待与广大同行精诚合作，为广大科研工作者提供优质的产品，高效的物流以及专业的售后服务。索莱宝感谢所有朋友的支持与帮助，您的支持是我们前进的动力和保障。让我们携手同行，共同创造美好的明天。
| 企业认证： | 已认证 | 企业性质： | 生产研发 |
|---|---|---|---|
| 主营产品： | Toluidine Blue ； 媒染兰 29 ； 聚蔗糖 70 ； Giemsa stain ； CY7-SE ； | 供货范围： | 试剂 |
| 产品目录： | 119907 | 品牌： | 索莱宝 |
| 纯度 | 品牌 | 规格 | 发货地 |
|---|---|---|---|
| - | 索莱宝 | 100mg / 250mg / 500mg | 北京 |
