SB216763,GSK3抑制剂

别名 3-(2,4-二氯苯基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮
英文别名 280744-09-4|SB 216763|3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione|SB216763|SB-216763|3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione|1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-|CHEMBL1
规格或纯度 ≥98%
英文名称 SB216763 生化机理 SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. SB 216763 also reduces pulmonary inflammation and fibrosis in a mouse model.Potent and selective GSK3 inhibitor (K i = 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC 50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective. 法律信息 Sold for only research purposes
储存温度 -20°C储存
运输条件 超低温冰袋运输 备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍 SB 216763
产品介绍： SB 216763是有效，选择性和ATP竞争性的 GSK-3 抑制剂，抑制GSK-3α和GSK-3β的 IC50 为34.3 nM。 SB 216763 SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line6and colorectal cancer cells.7 SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.