一种苯脲类除草剂，通过阻止 ATP 和 NADH 的形成来抑制光合作用。Diuron (2,500 ppm, dietary) 使雄性和雌性小鼠膀胱尿路上皮癌的发生率分别增加 73% 和 27%。
Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH.1 It decreases total respiration in roots of wheat by 50% and ground respiration by 100% when used at a concentration of 25 nM/ml.2 Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively.1 It increases the production of reactive oxygen species (ROS) in MCF-7 human breast adenocarcinoma and BeWo human placental choriocarcinoma cells when used at a concentration of 200 µM and reduces viability of BeWo, but not MCF-7, cells when used at concentrations of 50 and 200 µM.3 Formulations containing diuron have been used to control broadleaf and grass weeds and as a biocidal antifouling agent.
