CAS:612487-72-6|AZD1080

产品编号：A808085
化学名称：AZD1080
别名：2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile; 2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile; 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile
CAS号：612487-72-6
分子式：C₁₉H₁₈N₄O₂
分子量：334.37
类别：Research Tools;
应用：AZD1080 is a selective, orally active, brain permeable glycogen synthase kinase-3 (GSK3) inhibitor (1,2). AZD1080 has shown to rescue synaptic plasticity deficits in rodent brain and exhibit peripheral target engagement in humans.
参考文献：(1) Georgievska, B., et. al.: J. Neurochem., 125, 446 (2013)
(2) Chen, S., et al.: Drug Des Devel Ther. 10, 1225 (2016)

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