产品货号:D230785
产品名称:Demecolcine
Synonyms:(7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; Deacetylmethylcolchicine; Colchamin; NSC 3096; Omain; Omaine; Reichstein's F;
CAS号:477-30-5
分子式:C₂₁H₂₅NO₅
Appearance:Light Yellow to Very Dark Yellow Solid
Melting Point:73-75°C
分子量:371.43
Storage:-20°C, Hygroscopic
Solubility:Chloroform (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Standards; Enzyme Activators and Inhibitors;
应用:An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
参考文献:Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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