产品货号：A726300
产品名称：Apicidin
Synonyms:Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-
CAS号：183506-66-3
分子式：C₃₄H₄₉N₅O₆
Appearance:White to Off-White Solid
Melting Point:188-190ºC
分子量：623.78
Storage:4°C
Solubility:DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
Category:Research Tools; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用：Apicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.
参考文献：Larsen, T., et al.: J. Microbiol. Methods, 24, 135 (1995), Bode, H., et al.: ChemBioChem., 3, 619 (2002), Nielsen, K., et al.: J. Agric. Food Chem., 53, 8190 (2005),
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