产品货号：B675705
产品名称：(1R,2R)-Bortezomib
Synonyms:B-[(1R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid;
Impurity:Bortezomib USP Related Compound A
CAS号：1132709-15-9
分子式：C₁₉H₂₅BN₄O₄
Appearance:White to Off-White Solid
Melting Point:>167ºC (dec.)
分子量：384.24
Storage:-20°C
Solubility:Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
Category:Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用：(1R,2R)-Bortezomib is a diastereomer of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
参考文献：Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)
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