产品货号：B675720
产品名称：Bortezomib Trimer
Synonyms:N,N',N''-[2,4,6-Boroxintriyltris[[(1R)-3-methylbutylidene]imino[(1S)-2-oxo-1-(phenylmethyl)-2,1-ethanediyl]]]tris[2-pyrazinecarboxamide]; N,N',N''-[2,4,6-Boroxintriyltris[[(1R)-3-methylbutylidene]imino[(1S)-2-oxo-1-(phenylmethyl)-2,1-ethanediyl]]]tris-pyrazinecarboxamide;
CAS号：390800-88-1
分子式：C₅₇H₆₉B₃N₁₂O₉
Appearance:White to Off-White Solid
Melting Point:>117°C (dec.)
分子量：1098.67
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用：Bortezomib Trimer is derived from Bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
参考文献：Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)
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