产品货号：B809468
产品名称：tert-Butyl ((S)-2,6-Dimethyl-3-oxohept-1-en-4-yl)carbamate
Synonyms:(S)-4-(tert-Butoxycarbonylamino)-2,6-dimethyl-1-hepten-3-one; tert-Butyl ((4S)-2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate
CAS号：247068-81-1
Alternate CAS #
(R) enantiomer: B809453
分子式：C₁₄H₂₅NO₃
Appearance:Solid
分子量：255.35
Category:Building Blocks; Chiral Molecules;
应用：tert-Butyl ((S)-2,6-Dimethyl-3-oxohept-1-en-4-yl)carbamate is an intermediate in the synthesis of (S)-2-Amino-4-methyl-1-((S)-2-methyloxiran-2-yl)pentan-1-one Trifluoroacetate Salt which is an impurity of carfilzomib (C183460). Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
参考文献：Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);
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