产品货号：A628855
产品名称：Aminopterin-α-hyrazide
同义名称：N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid 5-Hydrazide
CAS 号:118359-33-4
分子式：C₁₉H₂₂N₁₀O₄
分子量：454.44
产品类别：Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：Aminopterin-α-hyrazide, is derivative of Aminopterin (A628850), which is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
参考文献:Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),
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