“Janus” dendrimers, i.e.dendrimers constituted of two dendrimeric wedges and terminated by two different functionalities, are reviewed. Both the synthetic aspects and the particular properties afforded by the presence of two different functions in two precise areas of the surface of the Janus dendrimers are reported. This review is organized depending on the type of internal structure (benzyl ether, phenylene, phosphorus, PAMAM, DAB, lysine, alkyl ether, ester, amide, etc.).