Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens†,10.1039/C5RA07165H

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens†

Lowrence Rene Christena,Shankar Subramaniam,Mohan Vidhyalakshmi,Vijayalakshmi Mahadevan,Aravind Sivasubramanian

RSC Advances Pub Date : 07/13/2015 00:00:00 , DOI:10.1039/C5RA07165H

Abstract

Nutraceutical pinostrobin displayed synergy with ciprofloxacin against diverse bacteria causing drastic 128 fold reduction in ciprofloxacin MIC in MRSA and significant antibiofilm effect against E. coli and P. aeruginosa at subinhibitory concentrations. Studies with NorA mutants of S.aureus revealed efflux inhibition of pinostrobin is mediated by efflux pumps other than NorA.