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Dynamic self-organization and polymorphism of microtubule assembly through active interactions with kinesin†
Yoshiki Tamura,Ryuzo Kawamura,Kazuhiro Shikinaka,Yoshihito Osada,Jian Ping Gong,Hiroyuki Mayama
Soft Matter Pub Date : 05/18/2011 00:00:00 , DOI:10.1039/C1SM05413A
Abstract

In this study, we show that the energy-dissipative active self-assembly of microtubules (MTs) via a kinesin-based motility system produces various MT assemblies such as bundle-, network-, and ring-shaped structures depending on the initial conditions. Structural polymorphism of the MT assembly is depicted through phase diagrams, and morphogenesis of the MT assembly is discussed based on the following factors: binding force between MTs and motility-driving force from kinesins. This study provides new insights into the energy-dissipative dynamic self-organization of biological systems.

Graphical abstract: Dynamic self-organization and polymorphism of microtubule assembly through active interactions with kinesin
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