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Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
Alexander P. Pulis,Kay Yeung,David J. Procter
Chemical Science Pub Date : 06/08/2017 00:00:00 , DOI:10.1039/C7SC01968H
Abstract

The direct functionalisation of allenes under copper catalysis enables efficient access to enantioenriched, densely functionalised molecules. In this review we explore the breadth and depth of a versatile reaction manifold, which involves the element-cupration of allenes to generate allyl copper intermediates that are subsequently coupled with diverse arrays of electrophiles.

Graphical abstract: Enantioselective copper catalysed, direct functionalisation of allenes via allyl copper intermediates
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