Alkaline anion exchange membrane water electrolysis (AEMWE) is considered to be an alternative to proton exchange membrane water electrolysis (PEMWE), owing to the use of non-noble meta/metal oxides in AEMWE. Here, we report a highly durable and low-cost AEM-based electrolysis cell with active spinel ferrite catalysts for hydrogen production. Ce-substituted MnFe₂O₄ was synthesized by a combustion method and investigated as the electro catalyst for oxygen evolution reaction (OER). Substitution of Ce in the cubic lattice of MnFe₂O₄ increases the conductivity of Ce_xMnFe_(2−x)O₄, which results in a negative shift in the OER onset potential. At 25 °C, the single cell with Ce_0.2MnFe_1.8O₄ exhibited a current density of 300 mA cm⁻² at 1.8 V. Notably, Ce_0.2MnFe_1.8O₄ demonstrates a durability of >100 hours in continuous electrolysis.