Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration†‡,10.1039/C2OB25407G

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration†‡

Philippa B. Cranwell,Matthew O'Brien,Duncan L. Browne,Peter Koos,Anastasios Polyzos,Miguel Peña-López,Steven V. Ley

Organic & Biomolecular Chemistry Pub Date : 03/21/2012 00:00:00 , DOI:10.1039/C2OB25407G

Abstract

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal–Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.