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Highly enantioselective hydrophosphonylation of imines catalyzed by SPINOL-phosphoric acid†
Yanyan Zhao,Xuejian Li,Fan Mo,Luhang Li,Xufeng Lin
RSC Advances Pub Date : 05/02/2013 00:00:00 , DOI:10.1039/C3RA40958A
Abstract

Chiral SPINOL-phosphoric acid is a highly enantioselective organocatalyst for asymmetric hydrophosphonylation of cinnamaldehyde-derived aldimines with diethyl phosphite at room temperature, affording α-amino phosphonates in 85–98% yields and 80–98% ee.

Graphical abstract: Highly enantioselective hydrophosphonylation of imines catalyzed by SPINOL-phosphoric acid
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