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A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives†
Vijay Nair,Vimal Varghese,Beneesh P. Babu,C. R. Sinu,Eringathodi Suresh
Organic & Biomolecular Chemistry Pub Date : 01/06/2010 00:00:00 , DOI:10.1039/B922981G
Abstract

Homoenolate generated from α,β-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component reaction.

Graphical abstract: A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives
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