960化工网
N-Heterocyclic carbene-catalyzed double acylation of enones with benzils†
Ken Takaki,Akira Ohno,Makoto Hino,Takashi Shitaoka,Kimihiro Komeyama,Hiroto Yoshida
Chemical Communications Pub Date : 08/26/2014 00:00:00 , DOI:10.1039/C4CC05436A
Abstract

Thiazolium carbene-catalyzed reaction of aromatic 1,2-diketones with enones in aprotic solvents gave double acylation products in good yields, whereas hydroacylation products formed by Stetter reaction were not detected at all. These results suggested the generation of aroyloxyenamine species from the 1,2-diketones instead of hydroxyenamines (Breslow intermediates).

Graphical abstract: N-Heterocyclic carbene-catalyzed double acylation of enones with benzils
平台客服
平台客服
平台在线客服