Microporous, hollow, or macroporous polymer spheres were prepared by a seed emulsion polymerisation method. Different from the conventional seeded emulsion polymerization, the sorbitan monooleate (Span 80) was added to the seeded emulsion polymerization. In this study, the monodisperse PS seeds prepared by dispersion polymerization were swelled by dibutyl phthalate (DBP), glycidyl methacrylate (GMA), divinylbenzene (DVB) and Span 80 successively. The effect of the amount of Span 80 on the morphology of microspheres was investigated. As different amount of Span 80 was added to the mixture, the poly(glycidyl methacrylate-divinylbenzene) (PGMA-DVB) microspheres showed a variety of morphologies containing microporous, hollow, and macroporous structure. In addition, uniform hollow particles with different pore size can be obtained through adjusting the amount of Span 80.