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Novel biotinylated bile acidamphiphiles: Micellar aggregates formation and interaction with hepatocytes†
Luca Rizzi,Marta Braschi,Nadia Vaiana,Gianpaolo Tibolla,Giuseppe Danilo Norata,Alberico Luigi Catapano,Sergio Romeo
Organic & Biomolecular Chemistry Pub Date : 03/03/2011 00:00:00 , DOI:10.1039/C0OB00878H
Abstract

Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.

Graphical abstract: Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes
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