Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates†,10.1039/C3CC47534D

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates†

Pedro M. S. D. Cal,Raquel F. M. Frade,Vijay Chudasama,Carlos Cordeiro,Stephen Caddick,Pedro M. P. Gois

Chemical Communications Pub Date : 11/05/2013 00:00:00 , DOI:10.1039/C3CC47534D

Abstract

Herein we present the synthesis of fluorescent 2-acetylbenzeneboronic acids that undergo B–N promoted conjugation with lysozyme and N-(2-aminoethyl) folic acid (EDA-FA), generating conjugates that are selectively recognized and internalized by cancer cells that over-express folic acid receptors.