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Stereoselective γ-lactam synthesis viapalladium-catalysed intramolecular allylation†
Donald Craig,Christopher J. T. Hyland,Simon E. Ward
Chemical Communications Pub Date : 06/09/2005 00:00:00 , DOI:10.1039/B504731E
Abstract

A novel route to the synthesis of 3-(tolylsulfonyl)-4,5-cis-disubstituted γ-lactams using a diastereoselective palladium-catalysed intramolecular allylation of amino acid-derived allylic carbonates has been developed.

Graphical abstract: Stereoselective γ-lactam synthesis via palladium-catalysed intramolecular allylation
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