Unprecedented incorporation of α-emitter radioisotope 213Bi into porphyrin chelates with reference to a daughter isotope mediated assistance mechanism†,10.1039/C1CC12455B

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Unprecedented incorporation of α-emitter radioisotope 213Bi into porphyrin chelates with reference to a daughter isotope mediated assistance mechanism†

Stéphane Le Gac,Nicolas Motreff,Patricia Remaud-Le Saec,Alain Faivre-Chauvet,Marie-Thérèse Dimanche-Boitrel,Alfred Morgenstern,Frank Bruchertseifer,Mohammed Lachkar,Bernard Boitrel

Chemical Communications Pub Date : 06/27/2011 00:00:00 , DOI:10.1039/C1CC12455B

Abstract

For the first time, α-emitter radioisotope ²¹³Bi has been incorporated into porphyrin chelates, with rates matching with the short period of the radionuclide. An in situ transmetalation mechanism involving the daughter isotope ²⁰⁹Pb is expected to boost the ²¹³Bi radiolabeling process.