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The development of a short route to the API ropinirole hydrochloride†
Zeshan Yousuf,Andrew K. Richards,Andrew N. Dwyer,Bruno Linclau,David C. Harrowven
Organic & Biomolecular Chemistry Pub Date : 08/28/2015 00:00:00 , DOI:10.1039/C5OB01739D
Abstract

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

Graphical abstract: The development of a short route to the API ropinirole hydrochloride
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