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Diastereoselective titanium-mediated construction of cis-2,3-ring annelated 1-(2′-chloroethyl)cyclopropanols
Frédéric Lecornué,Jean Ollivier
Chemical Communications Pub Date : 01/29/2003 00:00:00 , DOI:10.1039/B211642A
Abstract

Titanium(IV)-mediated cyclopropanation induced by reaction of cycloalkylmagnesium bromides 1ae in the presence of titanium tetraisopropoxide with ethyl β-chloropropionate 2 yielded cis-fused 1-(2′-chloroethyl)cyclopropanols 3be with diastereoselectivity highly depending on the ring size. Unexpected rearrangement products 5d,e were isolated in some cases.

Graphical abstract: Diastereoselective titanium-mediated construction of cis-2,3-ring annelated 1-(2′-chloroethyl)cyclopropanols
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