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Enantioselective synthesis of 2-substituted pyrrolidinesvia domino cross metathesis/intramolecular aza-Michael addition†
Hanbin Liu,Chuanqi Zeng,Jiajia Guo,Mengyao Zhang,Shouyun Yu
RSC Advances Pub Date : 12/04/2012 00:00:00 , DOI:10.1039/C2RA22374K
Abstract

A highly enantioselective intramolecular aza-Michael addition with enone carbamates catalyzed by chiral Brønsted acids was developed. A domino cross metathesis/aza-Michael addition for the preparation of 2-substituted pyrrolidines or benzopyrrolidines was also explored. The reactions described here provide an efficient asymmetric protocol for enantio-enriched heterocycles, especially 2-substituted pyrrolidines.

Graphical abstract: Enantioselective synthesis of 2-substituted pyrrolidines via domino cross metathesis/intramolecular aza-Michael addition
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