Formylation of phenols using formamidine acetate†
S. Hessam M. Mehr,Katsuya Fukuyama,Mahboobeh Maghami,Mark J. MacLachlan
Organic & Biomolecular Chemistry Pub Date : 12/21/2016 00:00:00 , DOI:10.1039/C6OB02727J
Abstract

We report a new method to formylate phenol derivatives using formamidine acetate and acetic anhydride. This general-purpose transformation is a significant improvement over many other methods and does not require high temperatures or the addition of strong acid or base. Mono-, di-, and tri-formylated product can be obtained, depending on the substrate and conditions used.

Graphical abstract: Formylation of phenols using formamidine acetate