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Iodobenzene catalysed synthesis of spirofurans and benzopyrans by oxidative cyclisation of vinylogous esters†
Marsewi Ngatimin,Raphael Frey,Cecily Andrews,David W. Lupton,Oliver E. Hutt
Chemical Communications Pub Date : 09/26/2011 00:00:00 , DOI:10.1039/C1CC15015D
Abstract

Vinylogous esters bearing para or metamethoxy benzyl groups undergo oxidative cyclisation with 5–20 mol% iodobenzene and m-CPBA to give spirofuran or benzopyran containing heterocycles. The reaction allows rapid generation of skeletal complexity in good to excellent yields via a novel oxidative cyclisation.

Graphical abstract: Iodobenzene catalysed synthesis of spirofurans and benzopyrans by oxidative cyclisation of vinylogous esters
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