A Lewis base-catalyzed [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkenes has been achieved under mild reaction conditions, affording various functionalized isoxazolidine derivatives as single diastereomers in moderate to excellent yields.
![Graphical abstract: Lewis base-catalyzed diastereoselective [3 + 2] cycloaddition reaction of nitrones with electron-deficient alkenes: an access to isoxazolidine derivatives](http://hg.y866.cn/compound/lib/scimg/usr/1/C7RA04264G.jpg)
