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Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C–N bond formation†
Xianhai Tian,Lina Song,Ertong Li,Qiang Wang,Wenquan Yu
RSC Advances Pub Date : 07/14/2015 00:00:00 , DOI:10.1039/C5RA11262A
Abstract

A one-pot I2-mediated annulation reaction of substrates containing diamino groups and aldehydes has been developed via oxidative C–N bond formation. This general and environmentally benign synthetic approach provides facile access to a variety of 1,3-diazaheterocyclic compounds, including quinazolinones, benzimidazoles, and cyclic amidines.

Graphical abstract: Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C–N bond formation
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