936-49-2 (2-苯基咪唑啉,2-Phenyl-2-imidazoline)

_100%

反应条件：

1.1 Solvents: tert-Butanol ; 30 min, rt
1.2 Reagents: tert-Butyl hypochlorite ; 2 h, 50 °C
1.3 Reagents: Sodium sulfite Solvents: Water

参考文献：

Facile preparation of 2-imidazolines from aldehydes with tert-butyl hypochlorite

Ishihara, Midori; Togo, Hideo, Synthesis, 2007, (13), 1939-1942

合成路线：1 步

_100%

反应条件：

1.1 Solvents: tert-Butanol ; 30 min, rt
1.2 Reagents: Potassium carbonate , Iodine ; 3 h, 70 °C
1.3 Reagents: Sodium sulfite Solvents: Water

参考文献：

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Ishihara, Midori; Togo, Hideo, Tetrahedron, 2007, 63(6), 1474-1480

合成路线：1 步

_100%

反应条件：

1.1 Solvents: tert-Butanol ; 30 min, rt
1.2 Reagents: Potassium carbonate , Iodine ; 3 h, 70 °C
1.3 Reagents: Sodium sulfite Solvents: Water

参考文献：

An efficient preparation of 2-imidazolines and imidazoles from aldehydes with molecular iodine and (diacetoxyiodo)benzene

Ishihara, Midori; Togo, Hideo, Synlett, 2006, (2), 227-230

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Hydrogen sulfide

参考文献：

Preparation of cyclic amidines

, Germany, , ,

合成路线：1 步

_99%

反应条件：

1.1 Solvents: Ethanol ; 1 h, reflux; cooled
1.2 Reagents: Iodine ; 2 h, reflux; reflux → rt
1.3 Reagents: Sodium thiosulfate Solvents: Water ; rt

参考文献：

Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C-N bond formation

Tian, Xianhai; Song, Lina; Li, Ertong; Wang, Qiang; Yu, Wenquan; et al, RSC Advances, 2015, 5(76), 62194-62201

合成路线：1 步

_99%

反应条件：

1.1 Solvents: Dichloromethane ; 30 min, 0 °C
1.2 Reagents: N-Bromosuccinimide ; overnight, rt
1.3 Reagents: Sodium dithionite Solvents: Water

参考文献：

One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates

Fujioka, Hiromichi; Murai, Kenichi; Kubo, Ozora; Ohba, Yusuke; Kita, Yasuyuki, Tetrahedron, 2007, 63(3), 638-643

合成路线：1 步

_99%

反应条件：

1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane ; 0 °C → rt

参考文献：

A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes

Fujioka, Hiromichi; Murai, Kenichi; Ohba, Yusuke; Hiramatsu, Atsushi; Kita, Yasuyuki, Tetrahedron Letters, 2005, 46(13), 2197-2199

合成路线：1 步

_98%

反应条件：

1.1 10 min, 80 °C

参考文献：

Synthesis of benzimidazole and quinoxaline derivatives using reusable sulfonated rice husk ash (RHA-SO3H) as a green and efficient solid acid catalyst

Shamsi-Sani, Mahnaz; Shirini, Farhad; Abedini, Masoumeh; Seddighi, Mohadeseh, Research on Chemical Intermediates, 2016, 42(2), 1091-1099

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Sulfur ; 2.5 min, rt

参考文献：

Microwave-assisted facile and convenient synthesis of imidazolines

Mohammadpoor-Baltork, I.; Abdollahi-Alibeik, M., Bulletin of the Korean Chemical Society, 2003, 24(9), 1354-1356

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: N-Bromosaccharin Solvents: Dichloromethane ; 20 min, rt
1.2 Reagents: Sodium hydroxide , Sodium pyrosulfite Solvents: Water ; rt

参考文献：

Green and rapid and instrumental one-pot method for the synthesis of imidazolines having potential anti-SARS-CoV-2 main protease activity

Azimi, Sabikeh; Merza, Muna S.; Ghasemi, Fatemeh; Dhahi, Hasan Ali; Baradarbarjastehbaf, Farid; et al, Sustainable Chemistry and Pharmacy, 2023, 34,

合成路线：1 步

_96%

反应条件：

1.1 Solvents: Dichloromethane ; 2 h, 0 °C
1.2 Reagents: N-Bromosuccinimide ; 0 °C; overnight, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 8

参考文献：

Synthesis of novel C-2 substituted imidazoline derivatives having the norbornene/dibenzobarrelene skeletons

Capan, Irfan; Servi, Suleyman, ARKIVOC (Gainesville, 2018, (7), 131-142

合成路线：1 步

_96%

反应条件：

1.1 Solvents: tert-Butanol ; 20 min, rt
1.2 Reagents: Sulfuric acid magnesium salt (1:1) , Hydrogen peroxide Catalysts: Sodium iodide Solvents: Water ; 80 °C
1.3 Reagents: Sodium dithionite Solvents: Water ; rt

参考文献：

A facile and efficient synthesis of 2-imidazolines from aldehydes using hydrogen peroxide and substoichiometric sodium iodide

Bai, Guo-yi; Xu, Kai; Chen, Guo-feng; Yang, Yong-hui; Li, Tian-yu, Synthesis, 2011, (10), 1599-1603

合成路线：1 步

13758-35-5

_96%

反应条件：

1.1 Solvents: Acetonitrile

参考文献：

Carbon-transfer reactions of Δ2-oxazolinium and -thiazolinium cations

Singh, Harjit; Sarin, Rakesh, Tetrahedron, 1986, 42(5), 1449-60

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Ferric phosphate Solvents: Water ; 7 h, reflux

参考文献：

Solvent-free and water-mediated synthesis of 2-substituted imidazolines using iron(III) phosphate

Behbahani, Farahnaz K.; Daloee, Toktam Sheibani; Ziaei, Parisa, Current Organic Chemistry, 2013, 17(3), 296-303

合成路线：1 步

_94%

反应条件：

1.1 Solvents: Water ; 30 min, rt
1.2 Reagents: Hydrogen peroxide Catalysts: 12-Tungstophosphoric acid , Tetrabutylammonium bromide Solvents: Water ; rt → 80 °C; 2 h, 80 °C

参考文献：

Green Synthesis of 2-Substituted Imidazolines using Hydrogen Peroxide Catalyzed by Tungstophosphoric Acid and Tetrabutylammonium Bromide in Water

Liu, Shuai; Li, Wang; Pang, Yiying; Xiao, Hesheng; Zhou, Yi; et al, Journal of Heterocyclic Chemistry, 2019, 56(3), 998-1002

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: 1,3-Bis(diphenylphosphino)propane , Palladium chloride Solvents: Toluene ; 16 h, reflux

参考文献：

Palladium-Catalyzed Multicomponent Synthesis of 2-Aryl-2-imidazolines from Aryl Halides and Diamines

Geden, Joanna V.; Pancholi, Alpa K.; Shipman, Michael, Journal of Organic Chemistry, 2013, 78(8), 4158-4164

合成路线：1 步

_94%

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Ethylene glycol ; 2 h, reflux; 20 mm Hg, 175 - 180 °C

参考文献：

Synthesis and acaricidal activity of 1-arylmethyl-2-arylimidazolidines

Kagabu, Shinzo; Sakou, Misa; Iwaya, Kazuko; Kiriyama, Kazuhisa, Nippon Noyaku Gakkaishi, 2001, 26(4), 393-398

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium acetate Catalysts: Iodine , (SP-4-2)-[(αR)-α-(Hydroxy-κO)benzeneacetato-κO][(αS)-α-(hydroxy-κO)benzeneacetat… Solvents: Toluene ; 20 min, 90 °C

参考文献：

Microwave-assisted cascade cycloaddition for C-N bond formation: an approach to the construction of 1,4,5,6-tetrahydropyrimidine and 2-imidazoline derivatives

An, Shujuan; Yin, Bing; Liu, Ping; Li, Xiangnan; Li, Chen; et al, Synthesis, 2013, 45(18), 2525-2532

合成路线：1 步

_93%

反应条件：

1.1 Catalysts: Phosphorus sulfide (P2S5) ; 5.5 min, heated; cooled; rt

参考文献：

Rapid and efficient synthesis of imidazolines and bisimidazolines under microwave and ultrasonic irradiation

Moghadam, Majid; Mohammadpoor-Baltork, Iraj; Mirkhani, Valiollah; Tangestaninejad, Shahram; Abdollahi-Alibeik, Mohammad; et al, Monatshefte fuer Chemie, 2007, 138(6), 579-583

合成路线：1 步

98-80-6

96-45-7

_93%