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Synthesis of alleneferrocenes through CuI-mediated Crabbé homologation reaction†
Shufeng Chen,Binglong Wang,Qing Yan,Jinxiang Shi,Haiying Zhao,Baoguo Li
RSC Advances Pub Date : 12/06/2012 00:00:00 , DOI:10.1039/C2RA22806H
Abstract

A concise and efficient method for the synthesis of bifunctional allene ferrocenes based on the modified Crabbé homologation reaction of ferrocenylacetylenes with paraformaldehyde promoted by CuI was developed. The presented synthesis proceeded readily with high compatibility of sensitive functional groups on the cyclopentadiene ring providing good to excellent yields of the desired products.

Graphical abstract: Synthesis of allene ferrocenes through CuI-mediated Crabbé homologation reaction
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