Psidials L and M and Psipinene, three novel meroterpenoids with significant protective activity toward cisplatin-damaged HK2 cells from the leaves of Psidium guajava
XinyiChen,YingdaZang,SenZhang,HaijieWu,JieMa,XiaoguangChen,ChuangjunLi,DongmingZhang
Abstract
Psidials L and M (1 and 2), two sesquiterpene-based meroterpenoids with unknown skeletons, and Psipinene (3), one novel monoterpene-based meroterpenoid, had been isolated from the leaves of Psidium guajava. Their structures were determined by spectroscopic data and calculated ECD spectra. The absolute structure of compound 1 was also determined by X-ray single crystal diffraction analysis. A plausible biosynthetic pathway for 1–2 was postulated. Compound 1 showed significant protective activity toward cisplatin-damaged HK2 cells.
