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68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers†
Brandon Nichols,Zhengtao Qin,Jun Yang,David R. Vera,Neal K. Devaraj
Chemical Communications Pub Date : 02/21/2014 00:00:00 , DOI:10.1039/C3CC49530B
Abstract

We have developed a 68Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

Graphical abstract: 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers
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