The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline
GiuliaApprato,GiuseppeErmondi,GiuliaCaron
Abstract
A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.
