A novel structurally simple calix[4]arene appended 8-amidoquinoline linked conjugate was synthesized and has been used as a turn-on fluorescence probe for Zn2+ and turn off fluorescence probe for F−. Moreover, this probe has been applied for Zn2+ detection in blood serum upto 8.7 μM and fluoride detection upto 22 nM in waste water samples, using emission spectra.
![Graphical abstract: An ICT based “turn on/off” quinoline armed calix[4]arene fluoroionophore: its sensing efficiency towards fluoride from waste water and Zn2+ from blood serum](http://hg.y866.cn/compound/lib/scimg/usr/1/C2AN36247C.jpg)
