Application of a 2-aryl indenylphosphine ligand in the Buchwald–Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions†,10.1039/C7OB01199G

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Application of a 2-aryl indenylphosphine ligand in the Buchwald–Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions†

Zi-Fei Wang,Si-Hao Zeng,Meng-Yue Gao

Organic & Biomolecular Chemistry Pub Date : 06/19/2017 00:00:00 , DOI:10.1039/C7OB01199G

Abstract

An efficient solvent-free protocol for the Buchwald–Hartwig cross-coupling reaction of aryl and heteroaryl chlorides with primary and secondary amines using the Pd(dba)₂/ligand 1 catalytic system has been developed. Notably, the catalytic system also efficiently catalyzed the reaction under aqueous conditions.