A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency†,10.1039/C2MB25347J

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A type III polyketide synthase from Rhizobium etli condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency†

Marimuthu Jeya,Tae-Su Kim,Manish Kumar Tiwari,Jinglin Li,Jung-Kul Lee

Molecular BioSystems Pub Date : 10/02/2012 00:00:00 , DOI:10.1039/C2MB25347J

Abstract

A novel type III polyketide synthase (RePKS) from Rhizobium etli produced a heptaketide pyrone using acetyl-CoA and six molecules of malonyl-CoA. Its catalytic efficiency (k_cat/K_m = 5230 mM⁻¹ min⁻¹) for malonyl CoA was found to be the highest ever reported. Molecular dynamics studies revealed the unique features of RePKS.