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Base promoted synthesis of activated cyclopropanes bearing homologated carbonyl groups via tandem Michael addition–intramolecular enolate trapping†
Alessio Russo,Alessandra Lattanzi
Organic & Biomolecular Chemistry Pub Date : 09/19/2011 00:00:00 , DOI:10.1039/C1OB06487H
Abstract

A simple base promoted intramolecular Michael initiated ring closure reaction of γ-hydroxyenone derived diphenyl phosphinates with 1,3-indandione, enabled the synthesis of novel activated cyclopropanes with homologated carbonyl moiety in good yield. Promising levels of enantioselectivity are achieved when using cinchona derivatives as promoters.

Graphical abstract: Base promoted synthesis of activated cyclopropanes bearing homologated carbonyl groups via tandem Michael addition–intramolecular enolate trapping
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