2. Stem Cell/Wnt Apoptosis
  3. β-catenin Apoptosis
  4. β-catenin-IN-9

β-catenin-IN-9 是一种 β-catenin 抑制剂，诱导细胞凋亡 (apoptosis)、细胞周期阻滞，并抑制结直肠癌细胞的迁移、侵袭和细胞上皮-间质转化 (EMT)。β-catenin-IN-9 抑制 β-catenin 和 vimentin 的转录，并在蛋白质水平上显著抑制 β-catenin。β-catenin-IN-9 可用于结直肠癌的研究。

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β-catenin-IN-9

β-catenin-IN-9 Chemical Structure

CAS No. : 3029462-00-5

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β-catenin-IN-9 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-catenin-IN-9 is a β-catenin inhibitor. β-catenin-IN-9 induces apoptosis, cell cycle arrest, and inhibits migration, invasion, and epithelial-mesenchymal transition (EMT) in colorectal cancer cells. β-catenin-IN-9 suppresses the transcription of β-catenin and vimentin, and significantly inhibits β-catenin at the protein level. β-catenin-IN-9 can be used for the research of colorectal cancer[1].

体外研究
(In Vitro)

β-catenin-IN-9 (compound 10d) 对 Colo-205 细胞表现出强效的细胞毒活性，IC50 值为 0.55 μM[1]。
β-catenin-IN-9 (0.55 μM; 48 小时; Colo-205) 展示出强大的细胞毒性活性，诱导凋亡，并抑制迁移和侵袭，并诱导结直肠癌细胞周期阻滞，导致总细胞死亡增加和 S 期细胞积累[1]。
β-catenin-IN-9 (0.55 μM; 48 小时; Colo-205) 显著抑制 β-catenin 蛋白水平并增加 vimentin 蛋白水平[1]。
β-catenin-IN-9 (0.55 μM; 48 小时; Colo-205) 显著抑制 β-catenin 和 vimentin 的基因表达，并诱导 E-cadherin 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-catenin-IN-9 相关抗体:

Cell Migration Assay[1]

Cell Line: Colo-205
Concentration: 0.55 μM
Incubation Time: 48 hours
Result: Significantly decreased the percentage of migrated cells by 50% and the percentage of invasive cells by 66%, indicating that it not only inhibits cell proliferation but also suppresses the migration and invasion capabilities of colorectal cancer cells.

Western Blot Analysis[1]

Cell Line: Colo-205
Concentration: 0.55 μM
Incubation Time: 48 hours
Result: Significantly inhibited the protein levels of β-catenin without affecting the protein levels of E-cadherin. The protein level of vimentin increased, which contrasts with its effect on vimentin mRNA level, indicating post-translational regulation.

RT-PCR[1]

Cell Line: Colo-205
Concentration: 0.55 μM
Incubation Time: 48 hours
Result: Significantly suppressed the transcription of β-catenin and vimentin, while inducing the expression of E-cadherin, suggesting that it inhibits the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.

Apoptosis Analysis[1]

Cell Line: Colo-205
Concentration: 0.55 μM
Incubation Time: 48 hours
Result: The late apoptosis was significantly up-regulated 14.8-fold, while necrosis significantly showed a 16-fold increase.

Cell Cycle Analysis[1]

Cell Line: Colo-205
Concentration: 0.55 μM
Incubation Time: 48 hours
Result: Led to cell cycle arrest at S-phase in colorectal cancer cells.
分子量

670.99

Formula

C40H58N6OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-catenin-IN-9 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

β-catenin-IN-93029462-00-5β-cateninApoptosisBeta cateninapoptosiscolorctal cancervimentincell cycle arrestand inhibits migrationinvasionand epithelial-mesenchymal transition (EMT)Inhibitorinhibitorinhibit

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