2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Mitochondrial Metabolism Reactive Oxygen Species (ROS) Caspase PARP
  4. 13'-Carboxy-δ-tocopherol

13'-Carboxy-δ-tocopherol 是长链维生素 E 的代谢产物。13'-Carboxy-δ-tocopherol 在癌细胞中表现出抗增殖活性。13'-Carboxy-δ-tocopherol 可激活 caspase-3、caspase-9，诱导 PARP-1 剪切，降低线粒体膜电位，促进活性氧 (ROS) 生成，并诱导细胞凋亡 (apoptosis)。13'-Carboxy-δ-tocopherol 可用于肝细胞癌的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

13'-Carboxy-δ-tocopherol

13'-Carboxy-δ-tocopherol Chemical Structure

CAS No. : 1160974-35-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

13'-Carboxy-δ-tocopherol 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3, caspase-9, causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases ROS formation, and drives apoptosis.13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma[1].

IC50 & Target[1]

Caspase-3

 

Caspase-7

 

Caspase-9

 

PARP-1

 

体外研究
(In Vitro)

13'-Carboxy-δ-tocopherol (Compound δ-13′-COOH) (24 h) 可强效抑制 HepG2 细胞的生长，24 h 孵育后的 EC50 为 6.5 μM[1]。
13'-Carboxy-δ-tocopherol (20 μM; 6 h) 可在孵育 6 小时后诱导 HepG2 细胞发生显著凋亡，激活 caspase-3、caspase-7、caspase-9 和 PARP-1 的剪切[1]。
13'-Carboxy-δ-tocopherol (10 μM; 6 h) 可显著升高 HepG2 细胞内 ROS 生成水平[1]。
13'-Carboxy-δ-tocopherol (10-20 μM; 1 h) 可降低 HepG2 细胞的线粒体膜电位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

13'-Carboxy-δ-tocopherol 相关抗体:

Western Blot Analysis[1]

Cell Line: human hepatoma HepG2 cells
Concentration: 20 μM
Incubation Time: 6 h
Result: Induced pronounced cleavage of caspase-3, caspase-7, caspase-9, and PARP-1, indicating activation of the intrinsic apoptotic pathway.
分子量

432.64

Formula

C27H44O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

13'-Carboxy-δ-tocopherol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13'-Carboxy-δ-tocopherol1160974-35-5ApoptosisMitochondrial MetabolismReactive Oxygen Species (ROS)CaspasePARPpoly ADP ribose polymerasehepatocellular carcinomaHepG2 cellsmitochondrial membrane potentialcaspase-3PARP-1caspase-7apoptosisreactive oxygen speciescaspase-9Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
13'-Carboxy-δ-tocopherol
目录号：
HY-N17653
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z